Jet Plane Fuel Anatomy,Used Woodworking Machinery For Sale In South Africa Canada,Rikon 8 Helical Jointer 10 - Downloads 2021
22.03.2021Not a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. This chapter summarizes the findings on carcinogenicity of jet-propulsion fuel 8 JP-8 presented in the National Research Council report Permissible Exposure Levels for Selected Military Fuel Vapors NRC and reviews additional studies on JP-8 and related mixtures, some of which were completed after the report was published.
The studies are summarized in Table Plane Dumps Jet Fuel In La Because the available data on JP-8 are sparse, the anztomy also reviewed carcinogenicity and genotoxicity data on some individual components of JP-8 that are identified as major components by weight percent or as carcinogens.
The subcommittee used the body of available information to assess the carcinogenic potential of JP-8 in humans. The review included epidemiologic studies of exposures to jet fuels and other. Human historical prospective cohort study of 2, men in Swedish ful forces. No evidence of association between exposure to jet fuel and lymphatic malignancies. Human population-based case-referent study of jte of 3, cancer patients.
Indication of excess risk of renal-cell carcinoma among aircraft mechanics and others with workplace exposures to jet fuel. No treatment-related tumors were observed in rats or mice of either sex; male rats had treatment-related accumulation of hyaline droplets in proximal convoluted tubular epithelium of kidney consistent with male alpha-2u-globulin nephropathy, a condition is specific to male rats.
No treatment-related tumors observed in rats; alpha-2u-globulin nephropathy, a condition specific to male rats, was observed. Males in the high-dose group had statistically nonsignificant increase in renal cell tumors; authors concluded that increase plzne tumors was due to alpha-2u-globulin accumulation and associated nephropathy. MD API had tumor-promoting effects; induced tumors were squamous cell carcinoma and papilloma of skin; treatment jet plane fuel anatomy dexamethasone inhibited tumor promotion.
Among the studies discussed in the report, the historical prospective cohort study of men in the Swedish armed forces Selden and Ahlborg and the population-based case-referent study of Siemiatycki et al.
Selden and Ahlborg reported that total cancer incidences were generally lower than expected in the cohort of 2, men in the Swedish armed forces, and they observed no associations between aircraft fuel and cancer at any site. The report noted as possible limitations of that study the short followup period years [yr] and selection bias. Siemiatycki et al. Screening analyses suggested an jet plane fuel anatomy between kerosene exposure and stomach cancer, but it was not confirmed by more in-depth analyses.
Anatkmy analyses indicated that people with exposure to jet fuel e. More in-depth analyses indicated an association between jet fuel and kidney cancer with an OR of 3. A dose-response relation was observed for jet-fuel exposure and increased risk of kidney cancer, and the authors judged the strength of the evidence of this association as moderate to strong. On the basis of in-depth analyses, the authors also found a nonsignificant excess of colorectal cancers associated with jet-fuel exposure and noted a report of a slight excess of colorectal cancer 22 observed, 18 expected among aircraft mechanics in Washington state.
The subcommittee concluded that the data did not provide a consistent body of evidence sufficiently robust to support the conclusion that exposure to military jet fuels carries an excess risk of cancer at any site. Among the studies discussed in the report, the subchronic inhalation studies of JP-8 Mattie et al. Those studies are discussed below with additional studies included in the current assessment. No long-term studies of the chronic health effects, including cancer, of JP-8 exposure have been conducted.
With regard to epidemiologic studies of related jet fuels, one additional study published after the release of the NRC report was identified Parent et jet plane fuel anatomy. Numerous studies of the carcinogenic potential of gasoline streams and related middle distillates have appeared in the open literature.
Parent et al. Some male patients with renal-cell carcinoma, 1, controls with cancer at other sites, and population-based controls were interviewed plae occupational histories and data on potential confounders. Multivariate logistic-regression models based on population, cancer controls, or a pool of both groups were used to estimate ORs.
With regard to aviation fuel, the authors reported indications of excess risks among aircraft mechanics OR, 2. Excess risk of renal-cell cancer was associated with workplace exposures to jet fuel OR, 3. The latter analyses were adjusted for nonoccupational and occupational potential confounders.
The authors noted that the high degree of correlation within the study population between exposures to jet fuel and aviation gasoline precluded assessment of the risks posed by each independently. The subcommittee is aware of a suspected cancer cluster in Fallon, Jet plane fuel anatomy, and that exposure to JP-8, originating from a naval base located in that town, is under investigation as a possible cause of the cluster exposures jet plane fuel anatomy other chemicals are being investigated as well.
Cuelsixteen persons currently or previously living in Fallon have been diagnosed with acute lymphocytic leukemia ALLa type of childhood cancer. No scientific studies were found that examined a potential relationship between ALL and ;lane exposure; therefore, the subcommittee jet plane fuel anatomy not reach any conclusion concerning exposure to JP-8 and this suspected cancer cluster.
No jet plane fuel anatomy are available on long-term rodent carcinogenicity studies of exposure to JP-8 by any route. Easley et al. DFM were administered to mice by the dermal route for 60 wk; however, the extremely limited reporting of skin-tumor findings in all treatment groups combined renders these studies uninformative with regard to carcinogenicity. Subchronic studies of day inhalation exposures to JP-8, with observation for an additional months mohave been conducted in rats and mice of both sexes Mattie et al.
Given the absence of jet plane fuel anatomy from carcinogenicity studies on JP-8, data on other middle-distillate fraction-derived mixtures with various degrees of similarity to JP-8 are discussed briefly below, including studies of mo inhalation exposures to JP-4 in rats and mice with observation for an additional 12 mo Bruner et al.
JP-8 has not been tested in lifetime rodent carcinogenicity jet plane fuel anatomy by the inhalation route. It has been tested in rats and mice of both sexes in studies with day exposures and then observation until the age of 24 mo Mattie et al.
No treatment-related tumors were seen in rats or mice of either sex. Male rats exhibited treatment-related accumulation of hyaline droplets in the proximal convoluted tubular epithelium of the kidney, which was consistent with male alpha 2u-globulin nephropathy. The jet plane fuel anatomy duration of exposure to JP-8 in the studies severely limits their usefulness for purposes jet plane fuel anatomy carcinogenicity assessment.
Other jet fuels have not been jet plane fuel anatomy in lifetime rodent carcinogenicity bioassays by the inhalation route, but mo exposure studies of JP-4 and day continuous-exposure studies of JP-5 discussed in the National Research Council report are briefly described here. Bruner et al.
In rats, an increase in renal-cell tumors three renal-cell adenomas, one carcinoma, and one sar. The authors attributed that increase in renal-cell fue to alpha 2u-globulin accumulation jwt associated nephropathy. Gaworski et al. Some animals were jet plane fuel anatomy immediately after cessation of exposure, and others were allowed to live unexposed for an additional 19 or 21 mo.
No treatment-related tumors were observed in rats or mice. One report of carcinogenicity studies of JP-8 administered dermally to mice was identified in the published literature Easley et al.
Jet fuels other than JP-8 have been tested for carcinogenicity in animal studies by the dermal route. Freeman et al. In the first protocol, jet fuel A was applied neat twice a week to the skin of C3H mice for 2 yr. In the second. In the second protocol, animals received a lower total dose of jet fuel A than those in the first protocol. Male mice were plaje for wk; female mice were sacrificed at 90 wk because of excessive irritation and ulceration at the site of application.
As summarized by Nesselmiddle distillate fractions MDFs have been tested in numerous lifetime mouse skin-painting studies over the last 20 yr. Early mouse skin-painting studies documenting the carcinogenicity of MDFs in mouse skin include those plqne Lewis et al. Skin irritation was observed in animals that received either the neat material or material diluted in toluene but not in animals that received material diluted in mineral oil.
The role of skin irritation in the development of skin tumors was investigated by Nessel et al. Treatment with the neat straight-run kerosene induced skin tumors and skin irritation; treatment with the diluted material produced neither. Skin tumors were induced in mice that received the neat jet plane fuel anatomy kerosene but not in mice that received equal doses of the straight-run kerosene in a diluted, nonirritating form.
JP-8 has not been tested in lifetime rodent carcinogenicity bioassays by the oral route. A day gavage study in male Sprague-Dawley jet plane fuel anatomy, although inadequate for purposes of carcinogenicity assessment, reported that JP-8 treatment was associated with the development of alpha 2u-globulin nephropathy Mattie et al. Other Jet Plane Fuel Angle relevant data not included in the National Research Council report but considered in the present assessment include those from tumor-initiation and -promotion studies of jet fuels and other middle distillates and fule on the carcinogenicity and genotoxicity of several jet plane fuel anatomy components of JP JP-8 has not been tested for tumor-initiating or -promoting activity.
Other MDFs have been tested for tumor-promoting activity in the same model system. In addition, hydrodesulfurized kerosene, hydrodesulfurized middle distillates, and lightly refined paraffinic oil have been tested for initiating activity with the model.
Those studies are briefly described below. Nessel et al. Diluted jet fuel A was not irritating to the skin, nor did it have any tumor-promoting effects. As summarized by NesselJet plane fuel anatomy have been tested in several initiation-promotion mouse skin-painting studies designed to investigate the multistage process of tumorigenesis. Both test materials were negative in the initiation assay compared with acetone-treated controls.
McKee et al. In the initiator test, the lightly refined paraffinic oil was applied to mouse skin 6 times over a 2-wk period, and then the promoter tetradecanoylphorbol acetate TPA was administered for a period of 1 yr. Lightly refined paraffinic oil was not a tumor initiator in this assay: only three of 30 animals that were treated with the test material and TPA developed skin tumors compared with nine of 30 control animals that were treated with acetone and TPA. In the anatomt test, the lightly refined paraffinic oil was applied to DMBA-treated mouse skin in a wk study.
Equal weekly doses of irritating and minimally irritating or nonirritating test jet plane fuel anatomy were compared to assess whether tumor promotion was a secondary response to these effects. Both lightly refined paraffinic oil and CC14 normal paraffins were tumor promoters, and both were irritating to the skin when applied undiluted. Dilution greatly reduced skin irritation and tumor-promoting activity. MD API had tumor-promoting effects, inducing squamous cell carcinoma and papilloma of the skin.
Acanthosis, a uniform thickening of the epidermis due. Inflammation of the skin was observed in some animals, as were excessive numbers of inflammatory cells in the dermis mixed population of neutrophils, lymphoid cells, histocytes, and mast cells. The author noted that subacute inflammation at early to midstudy points did not correlate well with tumor incidence and concluded that subacute inflammation was not a significant factor in tumor promotion by MDFs such as MD API The author suggested that induction of a lasting, mild hyperplasia is an essential but not sufficient requirement for development of skin anatony in this initiation-promotion model.
Treatment with dexamethasone, a potent antimitotic and anti-inflammatory agent that inhibits mouse epidermal DNA synthesis, reduced jet plane fuel anatomy and completely inhibited tumor fueo by MD API The available data on the carcinogenicity of JP-8 are sparse.
In light of that sparseness, and the small amount of data available on related mixtures, jet plane fuel anatomy as other jet fuels and MDFs, the carcinogenicity and genotoxicity of some jet plane fuel anatomy components jet plane fuel anatomy JP-8 that are identified as being among the top 10 constituents of the liquid fuel by weight anatkmy or as carcinogens are briefly discussed below.
Antaomy is present at low concentrations in JP-8, generally at 0. The International Agency planne Research on Cancer IARC has classified benzene as a known human carcinogen Group 1 on the basis of sufficient evidence that benzene causes leukemia in humans and anatom evidence of carcinogenicity in animals IARC Butylbenzene is one of the top 10 constituents of JP-8 by weight percentage.
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